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Hedrick was born in 1870 in Independence, Iowa. He attended Michigan Agricultural College (MAC), receiving a Bachelor of Science degree in 1893 and a Master of Science degree in 1895. He worked as Assistant Horticulturist at MAC from 1893 to 1895, while studying for his M.S.^[1]

From 1895 to 1905, Hedrick taught botany and horticulture at Oregon Agricultural College (1895–1897), Utah Agricultural College (1897–1899), and Michigan Agricultural College (1899–1905). He became a horticulturist at the New York State Agricultural Experiment Station in Geneva, New York in 1905. While in Geneva, Hedrick completed a Doctor of Science degree at Hobart College in 1913. He continued to work at the Station, which he directed from 1928 onwards, until 1937, when he retired.^[1]

Hedrick was a Fellow of the New York State Historical Association and a member of the American Society for Horticultural Science and American Pomological Society.^[1]

During his lifetime, he authored or co-authored more than a dozen publications, which are "still frequently consulted", on the subjects of pomology and horticulture.^[1] His monographs on fruits, including publications such as The Pears of New York (1922), "have become classic references on the fruit cultivars of the period".^[8]

Hedrick died in 1951.^[1]